Dual sEH/COX-2 Inhibition Using PTUPB—A Promising Approach to Antiangiogenesis-Induced Nephrotoxicity

Dual sEH/COX-2 Inhibition Using PTUPB—A Promising Approach to Antiangiogenesis-Induced Nephrotoxicity

Kidney injury from antiangiogenic chemotherapy is a significant clinical challenge, and we currently lack the ability to effectively treat it with pharmacological agents. Thus, we set out to investigate whether simultaneous soluble epoxide hydrolase (sEH) and cyclooxygenase-2 (COX-2) inhibition usin...

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Bibliographic Details
Main Authors: Wojciech K. Jankiewicz, Scott D. Barnett, Anna Stavniichuk, Sung Hee Hwang, Bruce D. Hammock, Jawad B. Belayet, A. H. Khan, John D. Imig
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-12-01
Series:Frontiers in Pharmacology
Subjects:
cyclooxygenase (COX)
soluble epoxide hydrolase (sEH)
vascular endothelial growth factor
nephrotoxicity
kidney injury
glomerular injury
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.744776/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.744776/full

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