Metabolomic Profiling of Angiotensin-II-Induced Abdominal Aortic Aneurysm in Ldlr<sup>−/−</sup> Mice Points to Alteration of Nitric Oxide, Lipid, and Energy Metabolisms

Metabolomic Profiling of Angiotensin-II-Induced Abdominal Aortic Aneurysm in Ldlr<sup>−/−</sup> Mice Points to Alteration of Nitric Oxide, Lipid, and Energy Metabolisms

Aneurysm is the second-most common disease affecting the aorta worldwide after atherosclerosis. While several clinical metabolomic studies have been reported, no study has reported deep metabolomic phenotyping in experimental animal models of aortic aneurysm. We performed a targeted metabolomics stu...

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Bibliographic Details
Main Authors: Juan Manuel Chao de la Barca, Alexis Richard, Pauline Robert, Maroua Eid, Olivier Fouquet, Lydie Tessier, Céline Wetterwald, Justine Faure, Celine Fassot, Daniel Henrion, Pascal Reynier, Laurent Loufrani
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:International Journal of Molecular Sciences
Subjects:
aneurysm
blood flow
hypertension
aorta
metabolomics
lipidomics
Online Access:https://www.mdpi.com/1422-0067/23/12/6387

Internet

https://www.mdpi.com/1422-0067/23/12/6387

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