A CRISPR Path to Finding Vulnerabilities and Solving Drug Resistance: Targeting the Diverse Cancer Landscape and Its Ecosystem

Abstract Cancer is the second leading cause of death globally, with therapeutic resistance being a major cause of treatment failure in the clinic. The dynamic signaling that occurs between tumor cells and the diverse cells of the surrounding tumor microenvironment actively promotes disease progressi...

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Bibliographic Details
Main Authors: Benjamin McLean, Aji Istadi, Teleri Clack, Mezzalina Vankan, Daniel Schramek, G. Gregory Neely, Marina Pajic
Format: Article
Language:English
Published: Wiley 2022-12-01
Series:Advanced Genetics
Subjects:
Online Access:https://doi.org/10.1002/ggn2.202200014