Crossing fitness valleys via double substitutions within codons

Crossing fitness valleys via double substitutions within codons

Abstract Background Single nucleotide substitutions in protein-coding genes can be divided into synonymous (S), with little fitness effect, and non-synonymous (N) ones that alter amino acids and thus generally have a greater effect. Most of the N substitutions are affected by purifying selection tha...

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Bibliographic Details
Main Authors: Frida Belinky, Itamar Sela, Igor B. Rogozin, Eugene V. Koonin
Format: Article
Language:English
Published: BMC 2019-12-01
Series:BMC Biology
Subjects:
Natural selection
Bacteria
Archaea
Short-term evolution
DNA context
Double substitutions
Online Access:https://doi.org/10.1186/s12915-019-0727-4

Internet

https://doi.org/10.1186/s12915-019-0727-4

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