HIF-1/2α-Activated RNF146 Enhances the Proliferation and Glycolysis of Hepatocellular Carcinoma Cells via the PTEN/AKT/mTOR Pathway

HIF-1/2α-Activated RNF146 Enhances the Proliferation and Glycolysis of Hepatocellular Carcinoma Cells via the PTEN/AKT/mTOR Pathway

Hypoxia microenvironment, a critical feature of hepatocellular carcinoma, contributes to hepatocarcinogenesis, tumor progression and therapeutic resistance. Hypoxia-inducible factors (HIFs)-activated target genes are the main effectors in hypoxia-induced HCC progression. In this study, we identified...

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Bibliographic Details
Main Authors: Guoliang Shen, Hao Wang, Ning Zhu, Qiliang Lu, Junwei Liu, Qiuran Xu, Dongsheng Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
hepatocellular carcinoma
hypoxia microenvironment
RNF146
pten
akt/mtor pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2022.893888/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2022.893888/full

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