Porcine model of progressive cardiac hypertrophy and fibrosis with secondary postcapillary pulmonary hypertension

Porcine model of progressive cardiac hypertrophy and fibrosis with secondary postcapillary pulmonary hypertension

Abstract Background Meaningful translational large animal models for cardiac diseases are indispensable for studying disease mechanisms, development of novel therapeutic strategies, and evaluation of potential drugs. Methods For induction of heart failure, cardiac hypertrophy and fibrosis, a bare me...

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Bibliographic Details
Main Authors: Mariann Gyöngyösi, Noemi Pavo, Dominika Lukovic, Katrin Zlabinger, Andreas Spannbauer, Denise Traxler, Georg Goliasch, Ljubica Mandic, Jutta Bergler-Klein, Alfred Gugerell, Andras Jakab, Zsuzsanna Szankai, Levente Toth, Rita Garamvölgyi, Gerald Maurer, Frederic Jaisser, Faiez Zannad, Thomas Thum, Sándor Bátkai, Johannes Winkler
Format: Article
Language:English
Published: BMC 2017-10-01
Series:Journal of Translational Medicine
Subjects:
Cardiac hypertrophy
PET-MRI imaging
Aortic isthmus stenosis
Translational large animal model
Gene expression
Online Access:http://link.springer.com/article/10.1186/s12967-017-1299-0

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http://link.springer.com/article/10.1186/s12967-017-1299-0

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