Loss of BCAA catabolism enhances Rab1A-mTORC1 signaling activity and promotes tumor proliferation in NSCLC

Loss of BCAA catabolism enhances Rab1A-mTORC1 signaling activity and promotes tumor proliferation in NSCLC

Background: Non-small cell lung cancer (NSCLC) is a leading cause of cancer death. Branched-chain amino acid (BCAA) homeostasis is important for normal physiological metabolism. Branched-chain keto acid dehydrogenase kinase (BCKDK) is a rate-limiting enzyme involved in BCAA degradation. BCAA metabol...

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Bibliographic Details
Main Authors: Meiting Xue, Jiawei Xiao, Wenna Jiang, Yanhui Wang, Duo Zuo, Haohua An, Li Ren
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:Translational Oncology
Subjects:
BCAA catabolism
BCKDK
Rab1A
mTORC1
NSCLC
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523323000827

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http://www.sciencedirect.com/science/article/pii/S1936523323000827

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