A Systematic Comparison of Antiandrogens Identifies Androgen Receptor Protein Stability as an Indicator for Treatment Response

A Systematic Comparison of Antiandrogens Identifies Androgen Receptor Protein Stability as an Indicator for Treatment Response

Antiandrogen therapy is a primary treatment for patients with metastasized prostate cancer. Whilst the biologic mechanisms of antiandrogens have been extensively studied, the operating protocols used for the characterization of these drugs were not identical, limiting their comparison. Here, the ant...

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Bibliographic Details
Main Authors: Tiziana Siciliano, Ingo H. Simons, Alicia-Marie K. Beier, Celina Ebersbach, Cem Aksoy, Robert I. Seed, Matthias B. Stope, Christian Thomas, Holger H. H. Erb
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Life
Subjects:
prostate cancer
AR signaling
nuclear receptor
therapy resistance
proteasomes
Online Access:https://www.mdpi.com/2075-1729/11/9/874

Internet

https://www.mdpi.com/2075-1729/11/9/874

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