Development of fast dispersing tablets of nebivolol: experimental and computational approaches to study formulation characteristics
Formulation of FDT (fast dispersing tablets) of nebivolol was optimized and evaluated using simplex lattice design (SLD). The influence of type and concentration of three disintegrants viz.,Ac-Di-Sol, Primojel and Polyplasdone XL on hardness, friability and disintegration time of tablet was studied....
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Universidade de São Paulo
2014-12-01
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| Series: | Brazilian Journal of Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000400956&lng=en&tlng=en |
| _version_ | 1811312988036005888 |
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| author | Rajamma Abburu Jayaramu Sateesha Shivally Boregowda Addanki Rahul Deva Varma Chandan Kalegowda |
| author_facet | Rajamma Abburu Jayaramu Sateesha Shivally Boregowda Addanki Rahul Deva Varma Chandan Kalegowda |
| author_sort | Rajamma Abburu Jayaramu |
| collection | DOAJ |
| description | Formulation of FDT (fast dispersing tablets) of nebivolol was optimized and evaluated using simplex lattice design (SLD). The influence of type and concentration of three disintegrants viz.,Ac-Di-Sol, Primojel and Polyplasdone XL on hardness, friability and disintegration time of tablet was studied. Response surface plot and the polynomial equations were used to evaluate influence of polymer on the tablet properties. Results were statistically analyzed using ANOVA, and a p < 0.05 was considered statistically significant. Results reveal that fibrous integrity and optimal degree of substitution in Primojel and Ac-Di-Sol are mainly responsible for the hardness of the tablet. Use of Polyplasdone in higher percentage in tablet formulation may result in high friability. Increase in concentration of Ac-Di-Sol increases the disintegration time but increased concentration of Primojel in the tablet formulation decreases the disintegration time. This is also evident from model terms for disintegration time with a high 'F' value of 14.69 and 'p' value of 0.0031 (<0.05). The reason could be that Primojel has higher swelling properties and an optimum hydration capacity, which favors fast disintegration of a tablet. In conclusion, careful selection of disintegrant for FDT could improve their properties. Use of Simplex Lattice Design for formulation development could simplify the formulation process and reduce the production cost. |
| first_indexed | 2024-04-13T10:46:18Z |
| format | Article |
| id | doaj.art-e907be431bcb4fb9ab196503a895fe03 |
| institution | Directory Open Access Journal |
| issn | 2175-9790 |
| language | English |
| last_indexed | 2024-04-13T10:46:18Z |
| publishDate | 2014-12-01 |
| publisher | Universidade de São Paulo |
| record_format | Article |
| series | Brazilian Journal of Pharmaceutical Sciences |
| spelling | doaj.art-e907be431bcb4fb9ab196503a895fe032022-12-22T02:49:48ZengUniversidade de São PauloBrazilian Journal of Pharmaceutical Sciences2175-97902014-12-0150495696310.1590/S1984-82502014000400031S1984-82502014000400956Development of fast dispersing tablets of nebivolol: experimental and computational approaches to study formulation characteristicsRajamma Abburu JayaramuSateesha Shivally BoregowdaAddanki Rahul Deva VarmaChandan KalegowdaFormulation of FDT (fast dispersing tablets) of nebivolol was optimized and evaluated using simplex lattice design (SLD). The influence of type and concentration of three disintegrants viz.,Ac-Di-Sol, Primojel and Polyplasdone XL on hardness, friability and disintegration time of tablet was studied. Response surface plot and the polynomial equations were used to evaluate influence of polymer on the tablet properties. Results were statistically analyzed using ANOVA, and a p < 0.05 was considered statistically significant. Results reveal that fibrous integrity and optimal degree of substitution in Primojel and Ac-Di-Sol are mainly responsible for the hardness of the tablet. Use of Polyplasdone in higher percentage in tablet formulation may result in high friability. Increase in concentration of Ac-Di-Sol increases the disintegration time but increased concentration of Primojel in the tablet formulation decreases the disintegration time. This is also evident from model terms for disintegration time with a high 'F' value of 14.69 and 'p' value of 0.0031 (<0.05). The reason could be that Primojel has higher swelling properties and an optimum hydration capacity, which favors fast disintegration of a tablet. In conclusion, careful selection of disintegrant for FDT could improve their properties. Use of Simplex Lattice Design for formulation development could simplify the formulation process and reduce the production cost.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000400956&lng=en&tlng=enNebivolol/comprimidos de dispersão rápidaPlanejamento de grade simplexComprimidos de dispersão rápida/capacidade de intumescimentoComprimidos de dispersão rápida/capacidade de hidrataçãoComprimidos de dispersão rápida/tempo de decomposição |
| spellingShingle | Rajamma Abburu Jayaramu Sateesha Shivally Boregowda Addanki Rahul Deva Varma Chandan Kalegowda Development of fast dispersing tablets of nebivolol: experimental and computational approaches to study formulation characteristics Brazilian Journal of Pharmaceutical Sciences Nebivolol/comprimidos de dispersão rápida Planejamento de grade simplex Comprimidos de dispersão rápida/capacidade de intumescimento Comprimidos de dispersão rápida/capacidade de hidratação Comprimidos de dispersão rápida/tempo de decomposição |
| title | Development of fast dispersing tablets of nebivolol: experimental and computational approaches to study formulation characteristics |
| title_full | Development of fast dispersing tablets of nebivolol: experimental and computational approaches to study formulation characteristics |
| title_fullStr | Development of fast dispersing tablets of nebivolol: experimental and computational approaches to study formulation characteristics |
| title_full_unstemmed | Development of fast dispersing tablets of nebivolol: experimental and computational approaches to study formulation characteristics |
| title_short | Development of fast dispersing tablets of nebivolol: experimental and computational approaches to study formulation characteristics |
| title_sort | development of fast dispersing tablets of nebivolol experimental and computational approaches to study formulation characteristics |
| topic | Nebivolol/comprimidos de dispersão rápida Planejamento de grade simplex Comprimidos de dispersão rápida/capacidade de intumescimento Comprimidos de dispersão rápida/capacidade de hidratação Comprimidos de dispersão rápida/tempo de decomposição |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000400956&lng=en&tlng=en |
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