Disentangling the Complexity of a Hexa-Herbal Chinese Medicine Used for Inflammatory Skin Conditions—Predicting the Active Components by Combining LC-MS-Based Metabolite Profiles and in vitro Pharmacology

Disentangling the Complexity of a Hexa-Herbal Chinese Medicine Used for Inflammatory Skin Conditions—Predicting the Active Components by Combining LC-MS-Based Metabolite Profiles and in vitro Pharmacology

Objectives: The purpose of this study is to investigate the anti-inflammatory activity of a hexa-herbal Chinese formula (HHCF) using spontaneously immortalized human epidermal keratinocytes (HaCaT) and to predict the active components by correlating the LC-MS-based metabolite profiles of the HHCF an...

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Bibliographic Details
Main Authors: Jennifer B. Chang, Majella E. Lane, Min Yang, Michael Heinrich
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Pharmacology
Subjects:
CCL17
Chinese herbal medicine formula
chemometric
HaCaT
inflammation
LC-MS-based metabolite profiles
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.01091/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.01091/full

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