The CD4 transmembrane GGXXG and juxtamembrane (C/F)CV+C motifs mediate pMHCII-specific signaling independently of CD4-LCK interactions

The CD4 transmembrane GGXXG and juxtamembrane (C/F)CV+C motifs mediate pMHCII-specific signaling independently of CD4-LCK interactions

CD4+ T cell activation is driven by five-module receptor complexes. The T cell receptor (TCR) is the receptor module that binds composite surfaces of peptide antigens embedded within MHCII molecules (pMHCII). It associates with three signaling modules (CD3γε, CD3δε, and CD3ζζ) to form TCR-CD3 comple...

وصف كامل

التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Mark S Lee, Peter J Tuohy, Caleb Y Kim, Philip P Yost, Katrina Lichauco, Heather L Parrish, Koenraad Van Doorslaer, Michael S Kuhns
التنسيق: مقال
اللغة:English
منشور في: eLife Sciences Publications Ltd 2024-04-01
سلاسل:eLife
الموضوعات:
CD4
T cell
TCR-CD3
evolution
Lck
pMHCII
الوصول للمادة أونلاين:https://elifesciences.org/articles/88225

الانترنت

https://elifesciences.org/articles/88225

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