HPV18 E6 inhibits α‐ketoglutarate‐induced pyroptosis of esophageal squamous cell carcinoma cells via the P53/MDH1/ROS/GSDMC pathway

HPV18 E6 inhibits α‐ketoglutarate‐induced pyroptosis of esophageal squamous cell carcinoma cells via the P53/MDH1/ROS/GSDMC pathway

Oncogene E6 plays a critical role in the development and progression of esophageal cancer caused by human papillomavirus (HPV) infection. Alpha‐ketoglutarate (AKG) is a key metabolite in the tricarboxylic acid cycle and has been widely used as a dietary and anti‐ageing supplement. In this study, we...

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Bibliographic Details
Main Authors: Duo Tang, Yuchen Zheng, Guozhen Wang, Chao Sheng, Zijia Liu, Biqi Wang, Qi Zong, Yuchen Zhang, Xiaonan Hou, Mengfei Yao, Zhixiang Zhou
Format: Article
Language:English
Published: Wiley 2023-08-01
Series:FEBS Open Bio
Subjects:
E6 oncogene
GSDMC
HPV
pyroptosis
ROS
α‐ketoglutarate
Online Access:https://doi.org/10.1002/2211-5463.13666

Internet

https://doi.org/10.1002/2211-5463.13666

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