Lineage-coupled clonal capture identifies clonal evolution mechanisms and vulnerabilities of BRAFV600E inhibition resistance in melanoma

Lineage-coupled clonal capture identifies clonal evolution mechanisms and vulnerabilities of BRAFV600E inhibition resistance in melanoma

Abstract Targeted cancer therapies have revolutionized treatment but their efficacies are limited by the development of resistance driven by clonal evolution within tumors. We developed “CAPTURE”, a single-cell barcoding approach to comprehensively trace clonal dynamics and capture live lineage-coup...

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Bibliographic Details
Main Authors: Ze-Yan Zhang, Yingwen Ding, Ravesanker Ezhilarasan, Tenzin Lhakhang, Qianghu Wang, Jie Yang, Aram S. Modrek, Hua Zhang, Aristotelis Tsirigos, Andrew Futreal, Giulio F. Draetta, Roel G. W. Verhaak, Erik P. Sulman
Format: Article
Language:English
Published: Nature Publishing Group 2022-10-01
Series:Cell Discovery
Online Access:https://doi.org/10.1038/s41421-022-00462-7

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https://doi.org/10.1038/s41421-022-00462-7

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