Role of Lysosomal Acidification Dysfunction in Mesenchymal Stem Cell Senescence

Role of Lysosomal Acidification Dysfunction in Mesenchymal Stem Cell Senescence

Mesenchymal stem cell (MSC) transplantation has been widely used as a potential treatment for a variety of diseases. However, the contradiction between the low survival rate of transplanted cells and the beneficial therapeutic effects has affected its clinical use. Lysosomes as organelles at the cen...

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Bibliographic Details
Main Authors: Weijun Zhang, Jinwu Bai, Kai Hang, Jianxiang Xu, Chengwei Zhou, Lijun Li, Zhongxiang Wang, Yibo Wang, Kanbin Wang, Deting Xue
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-02-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
mesenchymal stem cells
senescence
lysosomal acidification
V-ATPase
pH
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2022.817877/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2022.817877/full

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