TRAIL-R1-Targeted CAR-T Cells Exhibit Dual Antitumor Efficacy

TRAIL-R1-Targeted CAR-T Cells Exhibit Dual Antitumor Efficacy

Tumor necrosis factor–related apoptosis-inducing ligand receptor 1 (TRAIL-R1) has limited expression in normal tissues but was highly expressed in various types of tumors, making it an attractive target for cancer immunotherapy. Here, we utilized the single-chain variable fragment (scFv) from our pr...

Full description

Bibliographic Details
Main Authors: Yaru Nai, Li Du, Meiying Shen, Tingting Li, Jingjing Huang, Xiaojian Han, Feiyang Luo, Wang Wang, Da Pang, Aishun Jin
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-12-01
Series:Frontiers in Molecular Biosciences
Subjects:
TRAIL-R1
CAR-T
apoptosis
cytotoxicity
third generation
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2021.756599/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2021.756599/full

Similar Items