Adipose Stromal Cell-Derived Secretome Attenuates Cisplatin-Induced Injury In Vitro Surpassing the Intricate Interplay between Proximal Tubular Epithelial Cells and Macrophages

Adipose Stromal Cell-Derived Secretome Attenuates Cisplatin-Induced Injury In Vitro Surpassing the Intricate Interplay between Proximal Tubular Epithelial Cells and Macrophages

(1) Background: The chemotherapeutic drug cisplatin exerts toxic side effects causing acute kidney injury. Mesenchymal stromal cells can ameliorate cisplatin-induced kidney injury. We hypothesize that the MSC secretome orchestrates the vicious cycle of injury and inflammation by acting on proximal t...

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Bibliographic Details
Main Authors: Erika Rendra, Stefanie Uhlig, Isabell Moskal, Corinna Thielemann, Harald Klüter, Karen Bieback
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Cells
Subjects:
MSC secretome
proximal tubular epithelial cells
cisplatin
macrophages
acute kidney injury
oxidative stress
Online Access:https://www.mdpi.com/2073-4409/13/2/121

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https://www.mdpi.com/2073-4409/13/2/121

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