Label-free affinity screening, design and synthesis of inhibitors targeting the Mycobacterium tuberculosis L-alanine dehydrogenase.

Label-free affinity screening, design and synthesis of inhibitors targeting the Mycobacterium tuberculosis L-alanine dehydrogenase.

The ability of Mycobacterium tuberculosis (Mtb) to persist in its host may enable an evolutionary advantage for drug resistant variants to emerge. A potential strategy to prevent persistence and gain drug efficacy is to directly target the activity of enzymes that are crucial for persistence. We pre...

Full description

Bibliographic Details
Main Authors: Heung-Bok Kim, John-Paul Bacik, Ruilian Wu, Ramesh K Jha, Michaeline Hebron, Catherine Triandafillou, Joseph E McCown, Nam-In Baek, Jeong Han Kim, Young Jae Kim, Celia W Goulding, Charlie E M Strauss, Jurgen G Schmidt, Gauri S Shetye, Sungweon Ryoo, Eun-Kyeong Jo, Young Ho Jeon, Li-Wei Hung, Thomas C Terwilliger, Chang-Yub Kim
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0277670

Internet

https://doi.org/10.1371/journal.pone.0277670

Similar Items