Extrachromosomal circular DNA: a new potential role in cancer progression
Abstract Extrachromosomal circular DNA (eccDNA) is considered a circular DNA molecule that exists widely in nature and is independent of conventional chromosomes. eccDNA can be divided into small polydispersed circular DNA (spcDNA), telomeric circles (t-circles), microDNA, and extrachromosomal DNA (...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-06-01
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| Series: | Journal of Translational Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12967-021-02927-x |
| _version_ | 1818436243110756352 |
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| author | Tianyi Wang Haijian Zhang Youlang Zhou Jiahai Shi |
| author_facet | Tianyi Wang Haijian Zhang Youlang Zhou Jiahai Shi |
| author_sort | Tianyi Wang |
| collection | DOAJ |
| description | Abstract Extrachromosomal circular DNA (eccDNA) is considered a circular DNA molecule that exists widely in nature and is independent of conventional chromosomes. eccDNA can be divided into small polydispersed circular DNA (spcDNA), telomeric circles (t-circles), microDNA, and extrachromosomal DNA (ecDNA) according to its size and sequence. Multiple studies have shown that eccDNA is the product of genomic instability, has rich and important biological functions, and is involved in the occurrence of many diseases, including cancer. In this review, we focus on the discovery history, formation process, characteristics, and physiological functions of eccDNAs; the potential functions of various eccDNAs in human cancer; and the research methods employed to study eccDNA. |
| first_indexed | 2024-12-14T17:05:41Z |
| format | Article |
| id | doaj.art-e920897764d74e99a568ff2c6d00fc44 |
| institution | Directory Open Access Journal |
| issn | 1479-5876 |
| language | English |
| last_indexed | 2024-12-14T17:05:41Z |
| publishDate | 2021-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Translational Medicine |
| spelling | doaj.art-e920897764d74e99a568ff2c6d00fc442022-12-21T22:53:45ZengBMCJournal of Translational Medicine1479-58762021-06-0119111610.1186/s12967-021-02927-xExtrachromosomal circular DNA: a new potential role in cancer progressionTianyi Wang0Haijian Zhang1Youlang Zhou2Jiahai Shi3Nantong Key Laboratory of Translational Medicine in Cardiothoracic Diseases, and Research Institution of Translational Medicine in Cardiothoracic Diseases, Affiliated Hospital of Nantong UniversityResearch Center of Clinical Medicine, Affiliated Hospital of Nantong UniversityResearch Center of Clinical Medicine, Affiliated Hospital of Nantong UniversityNantong Key Laboratory of Translational Medicine in Cardiothoracic Diseases, and Research Institution of Translational Medicine in Cardiothoracic Diseases, Affiliated Hospital of Nantong UniversityAbstract Extrachromosomal circular DNA (eccDNA) is considered a circular DNA molecule that exists widely in nature and is independent of conventional chromosomes. eccDNA can be divided into small polydispersed circular DNA (spcDNA), telomeric circles (t-circles), microDNA, and extrachromosomal DNA (ecDNA) according to its size and sequence. Multiple studies have shown that eccDNA is the product of genomic instability, has rich and important biological functions, and is involved in the occurrence of many diseases, including cancer. In this review, we focus on the discovery history, formation process, characteristics, and physiological functions of eccDNAs; the potential functions of various eccDNAs in human cancer; and the research methods employed to study eccDNA.https://doi.org/10.1186/s12967-021-02927-xExtrachromosomal circular DNAMolecular mechanismsCancer progression |
| spellingShingle | Tianyi Wang Haijian Zhang Youlang Zhou Jiahai Shi Extrachromosomal circular DNA: a new potential role in cancer progression Journal of Translational Medicine Extrachromosomal circular DNA Molecular mechanisms Cancer progression |
| title | Extrachromosomal circular DNA: a new potential role in cancer progression |
| title_full | Extrachromosomal circular DNA: a new potential role in cancer progression |
| title_fullStr | Extrachromosomal circular DNA: a new potential role in cancer progression |
| title_full_unstemmed | Extrachromosomal circular DNA: a new potential role in cancer progression |
| title_short | Extrachromosomal circular DNA: a new potential role in cancer progression |
| title_sort | extrachromosomal circular dna a new potential role in cancer progression |
| topic | Extrachromosomal circular DNA Molecular mechanisms Cancer progression |
| url | https://doi.org/10.1186/s12967-021-02927-x |
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