The unfolded protein response affects readthrough of premature termination codons

The unfolded protein response affects readthrough of premature termination codons

Abstract One‐third of monogenic inherited diseases result from premature termination codons (PTCs). Readthrough of in‐frame PTCs enables synthesis of full‐length functional proteins. However, extended variability in the response to readthrough treatment is found among patients, which correlates with...

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Bibliographic Details
Main Authors: Yifat S Oren, Michelle L McClure, Steven M Rowe, Eric J Sorscher, Assaf C Bester, Miriam Manor, Eitan Kerem, Joseph Rivlin, Fouad Zahdeh, Matthias Mann, Tamar Geiger, Batsheva Kerem
Format: Article
Language:English
Published: Springer Nature 2014-04-01
Series:EMBO Molecular Medicine
Subjects:
nonsense‐mediated mRNA decay
premature termination codon
readthrough treatment
unfolded protein response
Online Access:https://doi.org/10.1002/emmm.201303347

Internet

https://doi.org/10.1002/emmm.201303347

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