Opposing, spatially-determined epigenetic forces impose restrictions on stochastic olfactory receptor choice

Opposing, spatially-determined epigenetic forces impose restrictions on stochastic olfactory receptor choice

Olfactory receptor (OR) choice represents an example of genetically hardwired stochasticity, where every olfactory neuron expresses one out of ~2000 OR alleles in the mouse genome in a probabilistic, yet stereotypic fashion. Here, we propose that topographic restrictions in OR expression are establi...

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Bibliographic Details
Main Authors: Elizaveta V Bashkirova, Nell Klimpert, Kevin Monahan, Christine E Campbell, Jason Osinski, Longzhi Tan, Ira Schieren, Ariel Pourmorady, Beka Stecky, Gilad Barnea, Xiaoliang Sunney Xie, Ishmail Abdus-Saboor, Benjamin M Shykind, Bianca J Marlin, Richard M Gronostajski, Alexander Fleischmann, Stavros Lomvardas
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-12-01
Series:eLife
Subjects:
olfaction
chromatin
nuclear architecture
patterning
heterochromatin
genomics
Online Access:https://elifesciences.org/articles/87445

Internet

https://elifesciences.org/articles/87445

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