Pharmacological inhibition of protein S-palmitoylation suppresses osteoclastogenesis and ameliorates ovariectomy-induced bone loss

Pharmacological inhibition of protein S-palmitoylation suppresses osteoclastogenesis and ameliorates ovariectomy-induced bone loss

Background: Excessive osteoclast formation disrupts bone homeostasis, thereby significantly contributing to pathological bone loss associated with a variety of diseases. Protein S-palmitoylation is a reversible post-translational lipid modification catalyzed by ZDHHC family of palmitoyl acyltransfer...

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Bibliographic Details
Main Authors: Linghui Ma, Liwei Zhang, Zirui Liao, Chunmei Xiu, Xi Luo, Na Luo, Lei Zhang, Guangxu He, Jianquan Chen
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Journal of Orthopaedic Translation
Subjects:
Protein S-palmitoylation
2-bromopalmitic acid
Osteoclastogenesis
Osteoporosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2214031X23000451

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http://www.sciencedirect.com/science/article/pii/S2214031X23000451

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