Short-Term Transcriptomic Points of Departure Are Consistent with Chronic Points of Departure for Three Organophosphate Pesticides across Mouse and Fathead Minnow

Short-Term Transcriptomic Points of Departure Are Consistent with Chronic Points of Departure for Three Organophosphate Pesticides across Mouse and Fathead Minnow

New approach methods (NAMs) can reduce the need for chronic animal studies. Here, we apply benchmark dose (concentration) (BMD(C))–response modeling to transcriptomic changes in the liver of mice and in fathead minnow larvae after short-term exposures (7 days and 1 day, respectively) to several dose...

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Bibliographic Details
Main Authors: Rubia Martin, Monique Hazemi, Kevin Flynn, Daniel Villeneuve, Leah Wehmas
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Toxics
Subjects:
benchmark dose
fathead minnow
mouse
organophosphate pesticides
transcriptional points of departure
Online Access:https://www.mdpi.com/2305-6304/11/10/820

Internet

https://www.mdpi.com/2305-6304/11/10/820

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