Selective Targeting of the Interconversion between Glucosylceramide and Ceramide by Scaffold Tailoring of Iminosugar Inhibitors

Selective Targeting of the Interconversion between Glucosylceramide and Ceramide by Scaffold Tailoring of Iminosugar Inhibitors

A series of simple C-alkyl pyrrolidines already known as cytotoxic inhibitors of ceramide glucosylation in melanoma cells can be converted into their corresponding 6-membered analogues by means of a simple ring expansion. This study illustrated how an isomerisation from iminosugar pyrrolidine toward...

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Bibliographic Details
Main Authors: Cécile Baudoin-Dehoux, Tessa Castellan, Frédéric Rodriguez, Arnaud Rives, Fabien Stauffert, Virginie Garcia, Thierry Levade, Philippe Compain, Yves Génisson
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:Molecules
Subjects:
iminosugars
glucocerebrosidase
pharmacological chaperones
glycosidase inhibitors
glucosylceramide synthase inhibitors
Gaucher disease
ligand docking
Online Access:http://www.mdpi.com/1420-3049/24/2/354

Internet

http://www.mdpi.com/1420-3049/24/2/354

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