Functional Crosstalk between PCSK9 Internalization and Pro-Inflammatory Activation in Human Macrophages: Role of Reactive Oxygen Species Release

Functional Crosstalk between PCSK9 Internalization and Pro-Inflammatory Activation in Human Macrophages: Role of Reactive Oxygen Species Release

Atherosclerosis is a cardiovascular disease caused mainly by dyslipidemia and is characterized by the formation of an atheroma plaque and chronic inflammation. Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a protease that induces the degradation of the LDL receptor (LDLR), which contribut...

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Bibliographic Details
Main Authors: Rafael I. Jaén, Adrián Povo-Retana, César Rosales-Mendoza, Patricia Capillas-Herrero, Sergio Sánchez-García, Paloma Martín-Sanz, Marina Mojena, Patricia Prieto, Lisardo Boscá
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:International Journal of Molecular Sciences
Subjects:
PCSK9
LDL
ROS
atherosclerosis
macrophage
cholesterol
Online Access:https://www.mdpi.com/1422-0067/23/16/9114

Internet

https://www.mdpi.com/1422-0067/23/16/9114

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