Catabolic Reductive Dehalogenase Substrate Complex Structures Underpin Rational Repurposing of Substrate Scope

Catabolic Reductive Dehalogenase Substrate Complex Structures Underpin Rational Repurposing of Substrate Scope

Reductive dehalogenases are responsible for the reductive cleavage of carbon-halogen bonds during organohalide respiration. A variety of mechanisms have been proposed for these cobalamin and [4Fe-4S] containing enzymes, including organocobalt, radical, or cobalt-halide adduct based catalysis. The la...

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Bibliographic Details
Main Authors: Tom Halliwell, Karl Fisher, Karl A. P. Payne, Stephen E. J. Rigby, David Leys
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Microorganisms
Subjects:
reductive dehalogenase
cobalamin
iron-sulphur clusters
bioremediation
EPR
X-ray crystallography
Online Access:https://www.mdpi.com/2076-2607/8/9/1344

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https://www.mdpi.com/2076-2607/8/9/1344

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