Diagnostic value of DNA or RNA-based metagenomic next-generation sequencing in lower respiratory tract infections

Diagnostic value of DNA or RNA-based metagenomic next-generation sequencing in lower respiratory tract infections

Objectives: We aimed to evaluate and compare the diagnostic performance of RNA-mNGS and DNA-mNGS workflow in bacterial pneumonia, fungal pneumonia and tuberculosis. Methods: A total of 134 cases suspected pneumonia undergoing both DNA and RNA based mNGS of bronchoalveolar lavage fluid (BALF) and als...

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Bibliographic Details
Main Authors: Jiafu Song, Suxia Liu, Yongpeng Xie, Chen Zhang, Caiyun Xu
Format: Article
Language:English
Published: Elsevier 2024-05-01
Series:Heliyon
Subjects:
Bacterial pneumonia
Fungal pneumonia
Tuberculosis
RNA-mNGS
DNA-mNGS
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844024067434

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http://www.sciencedirect.com/science/article/pii/S2405844024067434

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