Deletion of the murine ortholog of human 9p21.3 locus promotes atherosclerosis by increasing macrophage proinflammatory activity

Deletion of the murine ortholog of human 9p21.3 locus promotes atherosclerosis by increasing macrophage proinflammatory activity

BackgroundSeveral genome-wide association studies have reported a risk locus for coronary artery disease (CAD) in the 9p21. 3 chromosomal region. This region encodes a lncRNA in the INK4 locus (ANRIL) and its genetic variance has a strong association with CAD, but its mechanisms in atherogenesis rem...

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Bibliographic Details
Main Authors: Sanna Kettunen, Anna-Kaisa Ruotsalainen, Tiit Örd, Tuisku Suoranta, Janne Heikkilä, Minna U. Kaikkonen, Nihay Laham-Karam, Seppo Ylä-Herttuala
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
ANRIL
atherosclerosis
inflammation
coronary artery disease
Chr9p21.3
macrophage
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2023.1113890/full

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https://www.frontiersin.org/articles/10.3389/fcvm.2023.1113890/full

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