MYC functions as a switch for natural killer cell-mediated immune surveillance of lymphoid malignancies

MYC functions as a switch for natural killer cell-mediated immune surveillance of lymphoid malignancies

Oncogene addiction is considered as a cancer cell-autonomous phenomenon, but can also influence the host immune system. Here the authors show that MYC-driven lymphomagenesis is associated with a block in the maturation and effector functions of natural killer cells as a mechanism of tumor escape fro...

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Bibliographic Details
Main Authors: Srividya Swaminathan, Aida S. Hansen, Line D. Heftdal, Renumathy Dhanasekaran, Anja Deutzmann, Wadie D. M. Fernandez, Daniel F. Liefwalker, Crista Horton, Adriane Mosley, Mariola Liebersbach, Holden T. Maecker, Dean W. Felsher
Format: Article
Language:English
Published: Nature Portfolio 2020-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-16447-7

Internet

https://doi.org/10.1038/s41467-020-16447-7

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