MYC functions as a switch for natural killer cell-mediated immune surveillance of lymphoid malignancies
Oncogene addiction is considered as a cancer cell-autonomous phenomenon, but can also influence the host immune system. Here the authors show that MYC-driven lymphomagenesis is associated with a block in the maturation and effector functions of natural killer cells as a mechanism of tumor escape fro...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-06-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-16447-7 |
| _version_ | 1830299879424917504 |
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| author | Srividya Swaminathan Aida S. Hansen Line D. Heftdal Renumathy Dhanasekaran Anja Deutzmann Wadie D. M. Fernandez Daniel F. Liefwalker Crista Horton Adriane Mosley Mariola Liebersbach Holden T. Maecker Dean W. Felsher |
| author_facet | Srividya Swaminathan Aida S. Hansen Line D. Heftdal Renumathy Dhanasekaran Anja Deutzmann Wadie D. M. Fernandez Daniel F. Liefwalker Crista Horton Adriane Mosley Mariola Liebersbach Holden T. Maecker Dean W. Felsher |
| author_sort | Srividya Swaminathan |
| collection | DOAJ |
| description | Oncogene addiction is considered as a cancer cell-autonomous phenomenon, but can also influence the host immune system. Here the authors show that MYC-driven lymphomagenesis is associated with a block in the maturation and effector functions of natural killer cells as a mechanism of tumor escape from immunosurveillance. |
| first_indexed | 2024-12-19T08:16:51Z |
| format | Article |
| id | doaj.art-e934ba6da0f2436b96b15ce1e0b4094b |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T08:16:51Z |
| publishDate | 2020-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-e934ba6da0f2436b96b15ce1e0b4094b2022-12-21T20:29:28ZengNature PortfolioNature Communications2041-17232020-06-0111111710.1038/s41467-020-16447-7MYC functions as a switch for natural killer cell-mediated immune surveillance of lymphoid malignanciesSrividya Swaminathan0Aida S. Hansen1Line D. Heftdal2Renumathy Dhanasekaran3Anja Deutzmann4Wadie D. M. Fernandez5Daniel F. Liefwalker6Crista Horton7Adriane Mosley8Mariola Liebersbach9Holden T. Maecker10Dean W. Felsher11Division of Oncology, Departments of Medicine and Pathology, Stanford UniversityDivision of Oncology, Departments of Medicine and Pathology, Stanford UniversityDivision of Oncology, Departments of Medicine and Pathology, Stanford UniversityDivision of Oncology, Departments of Medicine and Pathology, Stanford UniversityDivision of Oncology, Departments of Medicine and Pathology, Stanford UniversityDivision of Oncology, Departments of Medicine and Pathology, Stanford UniversityDivision of Oncology, Departments of Medicine and Pathology, Stanford UniversityDivision of Oncology, Departments of Medicine and Pathology, Stanford UniversityDivision of Oncology, Departments of Medicine and Pathology, Stanford UniversityDivision of Oncology, Departments of Medicine and Pathology, Stanford UniversityThe Human Immune Monitoring Center (HIMC), Institute for Immunity, Transplantation and Infection, Stanford University School of MedicineDivision of Oncology, Departments of Medicine and Pathology, Stanford UniversityOncogene addiction is considered as a cancer cell-autonomous phenomenon, but can also influence the host immune system. Here the authors show that MYC-driven lymphomagenesis is associated with a block in the maturation and effector functions of natural killer cells as a mechanism of tumor escape from immunosurveillance.https://doi.org/10.1038/s41467-020-16447-7 |
| spellingShingle | Srividya Swaminathan Aida S. Hansen Line D. Heftdal Renumathy Dhanasekaran Anja Deutzmann Wadie D. M. Fernandez Daniel F. Liefwalker Crista Horton Adriane Mosley Mariola Liebersbach Holden T. Maecker Dean W. Felsher MYC functions as a switch for natural killer cell-mediated immune surveillance of lymphoid malignancies Nature Communications |
| title | MYC functions as a switch for natural killer cell-mediated immune surveillance of lymphoid malignancies |
| title_full | MYC functions as a switch for natural killer cell-mediated immune surveillance of lymphoid malignancies |
| title_fullStr | MYC functions as a switch for natural killer cell-mediated immune surveillance of lymphoid malignancies |
| title_full_unstemmed | MYC functions as a switch for natural killer cell-mediated immune surveillance of lymphoid malignancies |
| title_short | MYC functions as a switch for natural killer cell-mediated immune surveillance of lymphoid malignancies |
| title_sort | myc functions as a switch for natural killer cell mediated immune surveillance of lymphoid malignancies |
| url | https://doi.org/10.1038/s41467-020-16447-7 |
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