Frequency of multiple changes to prespecified primary outcomes of clinical trials completed between 2009 and 2017 in German university medical centers: A meta-research study.
<h4>Background</h4>Clinical trial registries allow assessment of deviations of published trials from their protocol, which may indicate a considerable risk of bias. However, since entries in many registries can be updated at any time, deviations may go unnoticed. We aimed to assess the f...
Main Authors: | , , , , , |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2023-10-01
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Series: | PLoS Medicine |
Online Access: | https://journals.plos.org/plosmedicine/article/file?id=10.1371/journal.pmed.1004306&type=printable |