Extracellular Matrix Derived from High Metastatic Human Breast Cancer Triggers Epithelial-Mesenchymal Transition in Epithelial Breast Cancer Cells through αvβ3 Integrin

Extracellular Matrix Derived from High Metastatic Human Breast Cancer Triggers Epithelial-Mesenchymal Transition in Epithelial Breast Cancer Cells through αvβ3 Integrin

Alterations in the composition and architecture of the extracellular matrix (ECM) can influence cancer growth and dissemination. During epithelial-mesenchymal transition (EMT), epithelial cells assume a mesenchymal cell phenotype, changing their adhesion profiles from cell-cell contacts to cell-matr...

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Bibliographic Details
Main Authors: Renata Machado Brandão-Costa, Edward Helal-Neto, Andreza Maia Vieira, Pedro Barcellos-de-Souza, Jose Morgado-Diaz, Christina Barja-Fidalgo
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:International Journal of Molecular Sciences
Subjects:
breast cancer
extracellular matrix
epithelial-mesenchymal transition
integrin signaling
disintegrin
Online Access:https://www.mdpi.com/1422-0067/21/8/2995

Internet

https://www.mdpi.com/1422-0067/21/8/2995

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