Dual Targeting of Stromal Cell Support and Leukemic Cell Growth by a Peptidic PKC Inhibitor Shows Effectiveness against B-ALL

Dual Targeting of Stromal Cell Support and Leukemic Cell Growth by a Peptidic PKC Inhibitor Shows Effectiveness against B-ALL

Mesenchymal stem cells (MSC) favour a scenario where leukemic cells survive. The protein kinase C (PKC) is essential to confer MSC support to leukemic cells and may be responsible for the intrinsic leukemic cell growth. Here we have evaluated the capacity of a chimeric peptide (HKPS), directed again...

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Bibliographic Details
Main Authors: Paola Fernanda Ruiz-Aparicio, Natalia-Del Pilar Vanegas, Gloria Inés Uribe, Paola Ortiz-Montero, Camila Cadavid-Cortés, Jimmy Lagos, Jessica Flechas-Afanador, Adriana Linares-Ballesteros, Jean-Paul Vernot
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:International Journal of Molecular Sciences
Subjects:
leukemic microenvironment
mesenchymal support
PKC
B-ALL
chimeric peptide
cell adhesion
Online Access:https://www.mdpi.com/1422-0067/21/10/3705

Internet

https://www.mdpi.com/1422-0067/21/10/3705

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