Increased Levels of cAMP by the Calcium-Dependent Activation of Soluble Adenylyl Cyclase in Parkin-Mutant Fibroblasts

Increased Levels of cAMP by the Calcium-Dependent Activation of Soluble Adenylyl Cyclase in Parkin-Mutant Fibroblasts

Almost half of autosomal recessive early-onset parkinsonism has been associated with mutations in PARK2, coding for parkin, which plays an important role in mitochondria function and calcium homeostasis. Cyclic adenosine monophosphate (cAMP) is a major second messenger regulating mitochondrial metab...

Full description

Bibliographic Details
Main Authors: Paola Tanzarella, Anna Ferretta, Simona Nicol Barile, Mariella Ancona, Domenico De Rasmo, Anna Signorile, Sergio Papa, Nazzareno Capitanio, Consiglia Pacelli, Tiziana Cocco
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:Cells
Subjects:
parkin
mitochondria
cAMP
calcium
Online Access:http://www.mdpi.com/2073-4409/8/3/250

Internet

http://www.mdpi.com/2073-4409/8/3/250

Similar Items