Activation of melanocortin receptor 4 with RO27-3225 attenuates neuroinflammation through AMPK/JNK/p38 MAPK pathway after intracerebral hemorrhage in mice

Activation of melanocortin receptor 4 with RO27-3225 attenuates neuroinflammation through AMPK/JNK/p38 MAPK pathway after intracerebral hemorrhage in mice

Abstract Background Neuroinflammation plays an important role in the pathogenesis of intracerebral hemorrhage (ICH)-induced secondary brain injury. Activation of melanocortin receptor 4 (MC4R) has been shown to elicit anti-inflammatory effects in many diseases. The objective of this study was to exp...

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Bibliographic Details
Main Authors: Shengpan Chen, Lianhua Zhao, Prativa Sherchan, Yan Ding, Jing Yu, Derek Nowrangi, Jiping Tang, Ying Xia, John H. Zhang
Format: Article
Language:English
Published: BMC 2018-04-01
Series:Journal of Neuroinflammation
Subjects:
Intracerebral hemorrhage
Melanocortin receptor 4
RO27-3225
Brain edema
Neuroinflammation
Online Access:http://link.springer.com/article/10.1186/s12974-018-1140-6

Internet

http://link.springer.com/article/10.1186/s12974-018-1140-6

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