Targeting carcinoembryonic antigen-expressing tumors using a novel transcriptional and translational dual-regulated oncolytic herpes simplex virus type 1

Targeting carcinoembryonic antigen-expressing tumors using a novel transcriptional and translational dual-regulated oncolytic herpes simplex virus type 1

VG2025 is a recombinant oncolytic herpes simplex virus type 1 (HSV-1) that uses transcriptional and translational dual regulation (TTDR) of critical viral genes to enhance virus safety and promote tumor-specific virus replication without reducing virulence. The TTDR platform is based on transcriptio...

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Bibliographic Details
Main Authors: Dmitry V. Chouljenko, Yanal M. Murad, I-Fang Lee, Zahid Delwar, Jun Ding, Guoyu Liu, Xiaohu Liu, Xuexian Bu, Yi Sun, Ismael Samudio, William Wei-Guo Jia
Format: Article
Language:English
Published: Elsevier 2023-03-01
Series:Molecular Therapy: Oncolytics
Subjects:
immunotherapy
oncolytic virus
HSV-1
cancer vaccine
virotherapy
microRNA
Online Access:http://www.sciencedirect.com/science/article/pii/S2372770523000116

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http://www.sciencedirect.com/science/article/pii/S2372770523000116

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