CLUH functions as a negative regulator of inflammation in human macrophages and determines ulcerative colitis pathogenesis

CLUH functions as a negative regulator of inflammation in human macrophages and determines ulcerative colitis pathogenesis

Altered mitochondrial function without a well-defined cause has been documented in patients with ulcerative colitis (UC). In our efforts to understand UC pathogenesis, we observed reduced expression of clustered mitochondrial homolog (CLUH) only in the active UC tissues compared with the unaffected...

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Main Authors: Shaziya Khan, Desh Raj, Shikha Sahu, Anam Naseer, Nishakumari C. Singh, Sunaina Kumari, Sharmeen Ishteyaque, Jyotsna Sharma, Promila Lakra, Madhav N. Mugale, Arun Kumar Trivedi, Mrigank Srivastava, Tulika Chandra, Vivek Bhosale, Manoj Kumar Barthwal, Shashi Kumar Gupta, Kalyan Mitra, Aamir Nazir, Uday C. Ghoshal, Amit Lahiri
Format: Article
Language:English
Published: American Society for Clinical investigation 2023-06-01
Series:JCI Insight
Subjects:
Gastroenterology
Online Access:https://doi.org/10.1172/jci.insight.161096

Internet

https://doi.org/10.1172/jci.insight.161096

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