Genomic and functional impact of Trp53 inactivation in JAK2V617F myeloproliferative neoplasms
Abstract Classical myeloproliferative neoplasms (MPNs) are characterized by the proliferation of myeloid cells and the risk of transformation into myelofibrosis or acute myeloid leukemia (AML) and TP53 mutations in MPN patients are linked to AML. However, JAK2V617F has been reported to impact the TP...
| Main Authors: | , , , , , , , , , , |
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| 格式: | 文件 |
| 语言: | English |
| 出版: |
Nature Publishing Group
2024-01-01
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| 丛编: | Blood Cancer Journal |
| 在线阅读: | https://doi.org/10.1038/s41408-023-00969-6 |