Genomic and functional impact of Trp53 inactivation in JAK2V617F myeloproliferative neoplasms

Genomic and functional impact of Trp53 inactivation in JAK2V617F myeloproliferative neoplasms

Abstract Classical myeloproliferative neoplasms (MPNs) are characterized by the proliferation of myeloid cells and the risk of transformation into myelofibrosis or acute myeloid leukemia (AML) and TP53 mutations in MPN patients are linked to AML. However, JAK2V617F has been reported to impact the TP...

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Bibliographic Details
Main Authors: Panhong Gou, Duanya Liu, Saravanan Ganesan, Evelyne Lauret, Nabih Maslah, Veronique Parietti, Wenchao Zhang, Véronique Meignin, Jean-Jacques Kiladjian, Bruno Cassinat, Stephane Giraudier
Format: Article
Language:English
Published: Nature Publishing Group 2024-01-01
Series:Blood Cancer Journal
Online Access:https://doi.org/10.1038/s41408-023-00969-6

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https://doi.org/10.1038/s41408-023-00969-6

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