Mesenchymal Stem Cells Exposed to Persistently High Glucocorticoid Levels Develop Insulin-Resistance and Altered Lipolysis: A Promising In Vitro Model to Study Cushing’s Syndrome

Mesenchymal Stem Cells Exposed to Persistently High Glucocorticoid Levels Develop Insulin-Resistance and Altered Lipolysis: A Promising In Vitro Model to Study Cushing’s Syndrome

BackgroundIn Cushing’s syndrome (CS), chronic glucocorticoid excess (GC) and disrupted circadian rhythm lead to insulin resistance (IR), diabetes mellitus, dyslipidaemia and cardiovascular comorbidities. As undifferentiated, self-renewing progenitors of adipocytes, mesenchymal stem cells (MSCs) may...

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Bibliographic Details
Main Authors: Mariangela Di Vincenzo, Marianna Martino, Vincenzo Lariccia, Giulia Giancola, Caterina Licini, Giovanni Di Benedetto, Giorgio Arnaldi, Monia Orciani
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-02-01
Series:Frontiers in Endocrinology
Subjects:
glucocorticoids
MSCs
lipolysis
glucose uptake
insulin resistance
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2022.816229/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2022.816229/full

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