Lunasin Improves the LDL-C Lowering Efficacy of Simvastatin via Inhibiting PCSK9 Expression in Hepatocytes and ApoE<sup>−/−</sup> Mice

Lunasin Improves the LDL-C Lowering Efficacy of Simvastatin via Inhibiting PCSK9 Expression in Hepatocytes and ApoE<sup>−/−</sup> Mice

Statins are the most popular therapeutic drugs to lower plasma low density lipoprotein cholesterol (LDL-C) synthesis by competitively inhibiting hydroxyl-3-methyl-glutaryl-CoA (HMG-CoA) reductase and up-regulating the hepatic low density lipoprotein receptor (LDLR). However, the concomitant up-regul...

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Bibliographic Details
Main Authors: Lili Gu, Yaqin Gong, Cheng Zhao, Yue Wang, Qinghua Tian, Gaoxin Lei, Yalin Liang, Wenfeng Zhao, Shuhua Tan
Format: Article
Language:English
Published: MDPI AG 2019-11-01
Series:Molecules
Subjects:
lunasin
simvastatin
proprotein convertase subtilisin/kexin type 9
low density lipoprotein receptor
low density lipoprotein cholesterol
hepatocyte nuclear factor-1α
Online Access:https://www.mdpi.com/1420-3049/24/22/4140

Internet

https://www.mdpi.com/1420-3049/24/22/4140

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