Effects of canagliflozin on myocardial microvascular density, oxidative stress, and proteomic profile

Effects of canagliflozin on myocardial microvascular density, oxidative stress, and proteomic profile

Introduction: Sodium-glucose cotransporter-2 inhibitors (SGLT2i) are cardioprotective, and canagliflozin (CANA), an SGLT2i, has been shown to improve perfusion, AMPK signaling, and oxidative stress in chronically ischemic myocardium. The aim of this study is to determine the effects of CANA in nonis...

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Bibliographic Details
Main Authors: Sharif A. Sabe, Cynthia M. Xu, Mohamed Sabra, Dwight D. Harris, Mark Broadwin, Krishna G. Bellam, Debolina Banerjee, Anny Usheva, M. Ruhul Abid, Frank W. Sellke
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Journal of Molecular and Cellular Cardiology Plus
Subjects:
Angiogenesis
Coronary microvasculature
Proteomics
SGLT2i
Online Access:http://www.sciencedirect.com/science/article/pii/S2772976123000223

Internet

http://www.sciencedirect.com/science/article/pii/S2772976123000223

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