A proliferative subtype of colorectal liver metastases exhibits hypersensitivity to cytotoxic chemotherapy
Abstract Personalized treatment approaches for patients with limited liver metastases from colorectal cancer are critically needed. By leveraging three large, independent cohorts of patients with colorectal liver metastases (n = 336), we found that a proliferative subtype associated with elevated CI...
Main Authors: | Liam F. Spurr, Carlos A. Martinez, Rohan R. Katipally, Soumya C. Iyer, Sian A. Pugh, John A. Bridgewater, John N. Primrose, Enric Domingo, Timothy S. Maughan, Michael I. D’Angelica, Mark Talamonti, Mitchell C. Posner, Philip P. Connell, Ralph R. Weichselbaum, Sean P. Pitroda |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2022-10-01
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Series: | npj Precision Oncology |
Online Access: | https://doi.org/10.1038/s41698-022-00318-z |
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