New Inhibitory Effects of Cilnidipine on Microglial P2X7 Receptors and IL-1β Release: An Involvement in its Alleviating Effect on Neuropathic Pain

New Inhibitory Effects of Cilnidipine on Microglial P2X7 Receptors and IL-1β Release: An Involvement in its Alleviating Effect on Neuropathic Pain

P2X7 receptors (P2X7Rs) belong to a family of ATP-gated non-selective cation channels. Microglia represent a major cell type expressing P2X7Rs. The activation of microglial P2X7Rs causes the release of pro-inflammatory cytokines such as interleukin-1β (IL-1β). This response has been implicated in ne...

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Bibliographic Details
Main Authors: Tomohiro Yamashita, Sawako Kamikaseda, Aya Tanaka, Hidetoshi Tozaki-Saitoh, Jose M. M. Caaveiro, Kazuhide Inoue, Makoto Tsuda
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Cells
Subjects:
IL-1β
P2X7R
microglia
neuropathic pain
inflammation
cilnidipine
Online Access:https://www.mdpi.com/2073-4409/10/2/434

Internet

https://www.mdpi.com/2073-4409/10/2/434

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