Single-Cell Transcriptome Analysis Identifies Subclusters with Inflammatory Fibroblast Responses in Localized Scleroderma

Single-Cell Transcriptome Analysis Identifies Subclusters with Inflammatory Fibroblast Responses in Localized Scleroderma

Localized scleroderma (LS) is an autoimmune disease with both inflammatory and fibrotic components causing an abnormal deposition of collagen in the skin and underlying tissue, often leading to disfigurement and disability. Much of its pathophysiology is extrapolated from systemic sclerosis (SSc) si...

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Bibliographic Details
Main Authors: Giffin Werner, Anwesha Sanyal, Emily Mirizio, Theresa Hutchins, Tracy Tabib, Robert Lafyatis, Heidi Jacobe, Kathryn S. Torok
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:International Journal of Molecular Sciences
Subjects:
localized scleroderma
single-cell RNA sequencing
fibroblasts
morphea
CXCR3 ligands
CXCL9
Online Access:https://www.mdpi.com/1422-0067/24/12/9796

Internet

https://www.mdpi.com/1422-0067/24/12/9796

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