Edwardsiella ictaluri T3SS effector EseN is a phosphothreonine lyase that inactivates ERK1/2, p38, JNK, and PDK1 and modulates cell death in infected macrophages

Edwardsiella ictaluri T3SS effector EseN is a phosphothreonine lyase that inactivates ERK1/2, p38, JNK, and PDK1 and modulates cell death in infected macrophages

ABSTRACT EseN is an Edwardsiella ictaluri type III secretion system effector with phosphothreonine lyase activity. In this work, we demonstrate that EseN inactivates p38 and c-Jun-N-terminal kinase (JNK) in infected head-kidney-derived macrophages (HKDMs). We have previously reported inactivation of...

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Bibliographic Details
Main Authors: Ranjan Koirala, Chanida Fongsaran, Tanisha Poston, Matthew Rogge, Bryan Rogers, Ronald Thune, Lidiya Dubytska
Format: Article
Language:English
Published: American Society for Microbiology 2023-12-01
Series:Microbiology Spectrum
Subjects:
Edwardsiella ictaluri
type III secretion system
T3SS effectors
EseN
apoptosis
phosphothreonine lyase
Online Access:https://journals.asm.org/doi/10.1128/spectrum.03003-23

Internet

https://journals.asm.org/doi/10.1128/spectrum.03003-23

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