Signaling logic of activity-triggered dendritic protein synthesis: an mTOR gate but not a feedback switch.

Changes in synaptic efficacy are believed to form the cellular basis for memory. Protein synthesis in dendrites is needed to consolidate long-term synaptic changes. Many signals converge to regulate dendritic protein synthesis, including synaptic and cellular activity, and growth factors. The coordi...

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Bibliographic Details
Main Authors: Pragati Jain, Upinder S Bhalla
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-02-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC2647780?pdf=render