Mutation of a Conserved Nuclear Export Sequence in Chikungunya Virus Capsid Protein Disrupts Host Cell Nuclear Import

Mutation of a Conserved Nuclear Export Sequence in Chikungunya Virus Capsid Protein Disrupts Host Cell Nuclear Import

Transmitted by mosquitoes; chikungunya virus (CHIKV) is responsible for frequent outbreaks of arthritic disease in humans. CHIKV is an arthritogenic alphavirus of the Togaviridae family. Capsid protein, a structural protein encoded by the CHIKV RNA genome, is able to translocate to the host cell nuc...

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Bibliographic Details
Main Authors: Susan C. Jacobs, Adam Taylor, Lara J. Herrero, Suresh Mahalingam, John K. Fazakerley
Format: Article
Language:English
Published: MDPI AG 2017-10-01
Series:Viruses
Subjects:
alphavirus
chikungunya virus
capsid protein
nuclear export
Online Access:https://www.mdpi.com/1999-4915/9/10/306

Internet

https://www.mdpi.com/1999-4915/9/10/306

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