Monitoring of kinetics and exhaustion markers of circulating CAR-T cells as early predictive factors in patients with B-cell malignancies

Monitoring of kinetics and exhaustion markers of circulating CAR-T cells as early predictive factors in patients with B-cell malignancies

PurposeCAR-T cell therapy has proven to be a disruptive treatment in the hematology field, however, less than 50% of patients maintain long-term response and early predictors of outcome are still inconsistently defined. Here, we aimed to optimize the detection of CD19 CAR-T cells in blood and to ide...

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Main Authors: Clara Beatriz García-Calderón, Belén Sierro-Martínez, Estefanía García-Guerrero, Luzalba Sanoja-Flores, Raquel Muñoz-García, Victoria Ruiz-Maldonado, María Reyes Jimenez-Leon, Javier Delgado-Serrano, Águeda Molinos-Quintana, Beatriz Guijarro-Albaladejo, Inmaculada Carrasco-Brocal, José-Manuel Lucena, José-Raúl García-Lozano, Cristina Blázquez-Goñi, Juan Luis Reguera-Ortega, María-Francisca González-Escribano, Marta Reinoso-Segura, Javier Briones, José Antonio Pérez-Simón, Teresa Caballero-Velázquez
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Immunology
Subjects:
CAR-T
flow cytometry
dPCR (digital PCR)
monitoring
biomarkers
B-ALL
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1152498/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1152498/full

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