In Chagas disease, transforming growth factor beta neutralization reduces Trypanosoma cruzi infection and improves cardiac performance

In Chagas disease, transforming growth factor beta neutralization reduces Trypanosoma cruzi infection and improves cardiac performance

Chronic Chagasic cardiomyopathy (CCC), a progressive inflammatory and fibrosing disease, is the most prominent clinical form of Chagas disease, a neglected tropical disease caused by Trypanosoma cruzi infection. During CCC, the parasite remains inside the cardiac cells, leading to tissue damage, inv...

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Bibliographic Details
Main Authors: Roberto Rodrigues Ferreira, Elen Mello de Souza, Glaucia Vilar-Pereira, Wim M. S. Degrave, Rayane da Silva Abreu, Marcelo Meuser-Batista, Nilma Valéria Caldeira Ferreira, Steve Ledbeter, Robert H. Barker, Sabine Bailly, Jean-Jacques Feige, Joseli Lannes-Vieira, Tania C. de Araújo-Jorge, Mariana Caldas Waghabi
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
cardiac fibrosis
Chagas disease
TGF-β
1D11
treatment
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2022.1017040/full

Internet

https://www.frontiersin.org/articles/10.3389/fcimb.2022.1017040/full

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