Enhanced reversal of ABCG2‐mediated drug resistance by replacing a phenyl ring in baicalein with a meta‐carborane

Success of chemotherapy is often hampered by multidrug resistance. One mechanism for drug resistance is the elimination of anticancer drugs through drug transporters, such as breast cancer resistance protein (BCRP; also known as ABCG2), and causes a poor 5‐year survival rate of human patients. Co‐tr...

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Bibliographic Details
Main Authors: Lydia Kuhnert, Robert Kuhnert, Menyhárt B. Sárosi, Cathleen Lakoma, Birte K. Scholz, Peter Lönnecke, Evamarie Hey‐Hawkins, Walther Honscha
Format: Article
Language:English
Published: Wiley 2024-02-01
Series:Molecular Oncology
Subjects:
Online Access:https://doi.org/10.1002/1878-0261.13527